Strain-level metagenomic assignment and compositional estimation for long reads with MetaMaps
نویسندگان
چکیده
منابع مشابه
Accurate Genome Relative Abundance Estimation Based on Shotgun Metagenomic Reads
Accurate estimation of microbial community composition based on metagenomic sequencing data is fundamental for subsequent metagenomics analysis. Prevalent estimation methods are mainly based on directly summarizing alignment results or its variants; often result in biased and/or unstable estimates. We have developed a unified probabilistic framework (named GRAMMy) by explicitly modeling read as...
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Article history: Received 23 February 2017 Received in revised form 16 May 2017 Accepted 21 May 2017 Available online xxxx
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Motivation Read assignment is an important first step in many metagenomic analysis workflows, providing the basis for identification and quantification of species. However ambiguity among the sequences of many strains makes it difficult to assign reads at the lowest level of taxonomy, and reads are typically assigned to taxonomic levels where they are unambiguous. We explore connections between...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2019
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10934-2